Two sample MR report
HLA-A_Endothelial Cell (Endo) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.1694039 | 0.4048094 | 0.6970895 |
| Weighted median | 6 | -0.1188835 | 0.0264387 | 0.0000069 |
| Inverse variance weighted | 6 | -0.1034989 | 0.0215560 | 0.0000016 |
| Simple mode | 6 | -0.1382763 | 0.0398481 | 0.0178477 |
| Weighted mode | 6 | -0.1378213 | 0.0444123 | 0.0267553 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.240483 | 4 | 0.1818943 |
| Inverse variance weighted | 6.951789 | 5 | 0.2242506 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1121147 | 0.1660403 | 0.5365525 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.25e-05 | 0 | TRUE | 0.4279028 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
